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Kinder COVID? Israeli lab probes whether virus mutating to



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amother
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Post Thu, Jun 25 2020, 10:07 am
Kinder COVID? Israeli lab probes whether virus mutating to become less vicious

As Italian doctor says virus has changed from an ‘aggressive tiger’ to a ‘wild cat,’ Tel Aviv virologist is tasked by Health Ministry to test ‘attenuation’ theory

Israeli researchers have started carrying out genome analysis to test whether the novel coronavirus is changing to become less vicious.

Evolutionary virologist Adi Stern told The Times of Israel that she has been tasked by the Health Ministry with conducting an analysis of dozens of samples from recent coronavirus patients, and comparing them to old samples.

“The hypothesis is that the virus has attenuated, which means it’s become less virulent, and there may be a genetic signal that shows this,” she said, adding that she was sequencing the genome of the virus in recent infections and contrasting it with samples from March.

Stern, who runs a Tel Aviv University virus lab, said that if this proves correct, it could explain why a smaller proportion of COVID-19 patients today end up being hospitalized in serious condition. It would have a major impact on the way governments and doctors plan for the rest of the pandemic, she commented, adding that the analysis will take several more weeks.

As Israel is getting underway with the research, an Italian doctor has been making headlines with claims that the virus is becoming gentler.

“It was like an aggressive tiger in March and April but now it’s like a wild cat,” Prof. Matteo Bassetti told The Sunday Telegraph.

Bassetti, the chief of infectious diseases at San Martino General Hospital in Genoa, said: “Even elderly patients, aged 80 or 90, are now sitting up in bed and they are breathing without help. The same patients would have died in two or three days, before.”

In Israeli hospitals, there are some similar suggestions.

“The disease is losing its virulence by mutation,” the leading infectious diseases specialist David Greenberg told The Times of Israel.

A top World Health Organization doctor, however, has spoken out against such claims.

“We need to be careful: this is still a killer virus,” WHO emergencies director Michael Ryan told a virtual press conference on June 1, following earlier claims that the virus was weakening. “We need to be exceptionally careful not to create a sense that, all of a sudden, the virus, by its own volition, has now decided to be less pathogenic. That is not the case at all.”

But Greenberg, head of pediatrics and the pediatric infectious diseases unit at Soroka University Medical Center in Beersheba, disagrees, and thinks there is a sound logic why a virus may undergo a softening.

”It seems to adapt to the human being, and doesn’t want to kill the hosts but live on in them and flourish. We can see it all over the world, not just in Israel,” he said.

Greenberg believes this helps explain why the proportion of elderly people among the newly infected in Israel is low compared to earlier in the pandemic — while he would expect it to be higher as, post-lockdown, the elderly now have more contact with kids. He thinks that a softening of the virus means that the elderly are more prone to have the virus but remain unaware.

“A lot of old people are mixing with children, but the virus mutates; [there could be] lots of parents and grandparents who don’t know they have it,” he said.

Stern, who is testing the theory, is more circumspect. She suggested that the hypothesis that the virus is weakening is something of a long shot, saying that a range of other factors, including increased medical knowledge, may be improving outcomes.

Nevertheless, she is “hopeful,” and commented: “If this is true then it’s important to realize it, because it would affect policymaking.

“A lot of the models that are trying to predict the virus spread, such as how many people with the disease will need hospitalization and ventilation, are based on what we’ve seen so far. If the virus is becoming less virulent, this is important to understand.”

https://www.timesofisrael.com/.....ious/
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shabbatiscoming




 
 
    
 

Post Thu, Jun 25 2020, 10:20 am
I love how every time I have seen this article being circulated people seem to somehow skip right over the below paragraph in the middle of the article:

“We need to be careful: this is still a killer virus,” WHO emergencies director Michael Ryan told a virtual press conference on June 1, following earlier claims that the virus was weakening. “We need to be exceptionally careful not to create a sense that, all of a sudden, the virus, by its own volition, has now decided to be less pathogenic. That is not the case at all.”

Mutating most probably, but still dangerous Sad
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amother
OP


 

Post Thu, Jun 25 2020, 10:22 am
shabbatiscoming wrote:
I love how every time I have seen this article being circulated people seem to somehow skip right over the below paragraph in the middle of the article:

“We need to be careful: this is still a killer virus,” WHO emergencies director Michael Ryan told a virtual press conference on June 1, following earlier claims that the virus was weakening. “We need to be exceptionally careful not to create a sense that, all of a sudden, the virus, by its own volition, has now decided to be less pathogenic. That is not the case at all.”

Mutating most probably, but still dangerous Sad


Of course. But, there does seem to be some change, either virus mutating or maybe the heat, that is causing it to have less impact now in Israel and other countries than it had in March/April. There don't seem to be many new hospitalizations or serious cases even with the huge jump in new daily cases.
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banana123




 
 
    
 

Post Thu, Jun 25 2020, 10:37 am
amother [ OP ] wrote:
Of course. But, there does seem to be some change, either virus mutating or maybe the heat, that is causing it to have less impact now in Israel and other countries than it had in March/April. There don't seem to be many new hospitalizations or serious cases even with the huge jump in new daily cases.

That's probably because of the demographics of who is testing positive.

Those at risk aren't sending their children back and they are essentially still under lockdown.
Plus many of us not considered to be at risk are wary and still hardly going anywhere.

So that leaves only a part of the young, low-risk sector of the population to contract it.

And, remember, this virus doesn't disappear within a week or two, and it can turn very serious very quickly. We may yet see a spike in hospitalizations.

But certainly improved treatment protocols and newer research will help mitigate the effects of reopening.
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